For women or couples deciding to undertake IVF to have baby it is often associated with great anticipation of a positive outcome.
While there have been huge advances in assisted reproduction over the last decades, the chance of having a baby from IVF across all centres, averages around 50% for women under 35years, for the first attempt. After this age, pregnancy rates do decline due to diminishing egg numbers and quality but also increasing miscarriage rates even if the woman is experiencing regular cycles!
Although there is wide biological variation, from the statistics we know women under 35 years have the best baseline fertility and therefore are the most comparable across centres. As a result the Canadian registry for ART outcomes across Canadian centres looks at this age group. …more
Statistics provides guidance for probability of outcome and intervention but for the individual it may not apply. For example:
- Women over 40 can still get pregnant, naturally as well as through IVF but statistically the chance is less
- Equally in reverse, some women under 35yrs can have unexpected low ovarian reserve.
- Younger men may surprisingly have poor sperm quality whereas some older men may not. This is opposite to the usual trend where male fertility does decline (although more gradually than in women) with age.
On a personal level it is the individual couple’s profile that is important
Successful IVF treatment resulting in pregnancy is influenced heavily by your own characteristics, particularly female age, ovarian reserve (the number of follicles seen in the ovary), sperm quality, general medical health of both the man and woman and whether you are overweight, smoke or take recreational or therapeutic drugs.
According to CARTR (Canadian ART Registry) pregnancy rates per cycle from all Canadian clinics in 2013 was 27% and per embryo transfer 38% in all age groups.
The highest pregnancy rate per embryo transfer of 46% was reported in patients younger than 35 years old.
At this Centre for the same group –i.e.women under 35yrs -the pregnancy rate per cycle averaged over 2013-2014 is 50%
The pregnancy rate per transfer is 53% for the same group….more
The number of cycles in this age group was >25
For women 43 and under the pregnancy rate per OPU 28% and per ET 32% (2013)
Hopefully pregnancy will be achieved from the fresh embryo transfer following the first cycle.
Should this not occur the chance of a pregnancy increases with each subsequent frozen-thawed embryo transfer providing this first cycle yielded spare embryos for freezing more
A high clinical pregnancy rate can be at the expense of a high multiple pregnancy rate following transfer of 2 or more embryos.
Multiple pregnancies, such as twins, are associated with a high risk of complications for mother and child and hence, the goal is to achieve a high clinical pregnancy rate from an elective single embryo transfer (eSET) .
For certain patients it is however justifiable to transfer more than one embryo for example is situations of advanced female age, a history of previous failed cycles and/or perceived poor embryo quality.
We would encourage patients when comparing different centres , to look at the median age groups of patients treated at the centre, cancellation policies or restrictions for age and ovarian reserve, as these factors may bias pregnancy rates to appear more favorable adding to confusion.
Our Success Rates
|Elective Single Embryo Transfer (eSET)|
|Clinical Pregnancy Rate per eSET||55%|
|Cumulative Clinical Pregnancy Rate per cycle 2||85%|
2Embryos from same stimulation retrieval cycle (eSET + FET)
National Average clinical pregnancy rate of eSET in patients <35 is 49%
|Frozen Embryo Transfer (FET) - Vitrification Techniques 3|
|All ages combined to 43|
|Clinical Pregancy Rate per FET 3||55%|
|Survival Rate after Warming 3||96%|
National Average clinical pregnancy rate per FET is 32%
Although accredited IVF centres can do much to optimize pregnancy outcomes particuarly with a highly individualized approach, technology and intervention can only go so far.
We try to guide and counsel you as much as possible to ensure you are well informed of probabilities of success in the context of your personal profile while being sensitive to your desires.
What is a clinical pregnancy?..more
A clinical pregnancy is defined as one with an ultrasound confirmed gestational sac i.e. an early implanted embryo.
This definition is the standard used in defining clinical pregnancy rates following IVF treatment and typically is expressed as per IVF cycle start as shown in our Infographic and table.
What is vitrification?..more
Vitrification is the latest cryopreservation technique that improves survival of embryos following “warming”.
This technique has made egg freezing a viable fertility preservation option and is no longer considered experimental
Vitrification techniques (for both oocyte and embryo cryopreservation) have been used at Grace Fertility since 2013 achieving a high survival rate after “warming” the blastocysts (see table). These successful results have provided reassurance when counseling our patients for eSET. more
Does the center provide care to couples with complex problems or do they use prior screening results to determine treatment eligibility?..more
Yes, we frequently see patients who have either been cancelled, unsuccesful or denied treament elsewher either to use their own eggs, or because of other issues. A significant number of these patients do achieve success but unfortunately many do not. Proceeding through fertility treatment does require careful counselling so expectations are realistically dealt with. We also appreciate hope and the chance to try can be very important and when there is healthy baby at the end for you it is of immense joy for all of us.
Patients are accepted for donor eggs up to the age of natural menopause (50yrs) Even in the late 40’s obstetric complication start to rise and thus your general state of health must be carefully assessed, if pregnancy is desired in your mid to late 40’s.
Does the center routinely perform embryo transfers at the blastocyst stage (Day 5) of development?..more
Yes, Day 5 transfers occur in the majority of cases.
Occasionally, in patients with few embryos or poor cleavage a Day 3 transfer will be suggested in the hope nature will prevail over nurture. This does not necessarily mean pregnancy will not occur as poor quality embryo(s) transferred back, in this kind of instance, have resulted in pregnancy followed by live births.